Endocrine Abstracts

Background: Fixed-dose radioactive iodine therapy (RAI) is one of the standard therapy for Graves’ disease (GD). However, optimal RAI dose to achieve hypothyroidism in GD has been controversial.Methods: The clinical outcome of 124 patients with GD treated with a RAI between Apr. 2004 and Dec. 2014 was analyzed retrospectively. Responder group was defined as patients who were rendered hypothyroid by the RAI. Thyroid volume (TV) was assessed with sono...

Background: Struma ovarii is a germ cell tumor of the ovary containing ≥ 50% thyroid tissue and malignant struma ovarii (MSO) is a very rare disease containing papillary or follicular thyroid carcinomas (FTC). There is no consensus on optimal management for patients with MSO and no data on radioactive iodine (RAI) responsiveness. Here, we report two cases with RAI refractory MSO with NRAS mutation detected by next-generation sequencing (NGS). Case ...